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  • Toxicant-Receptor Interactions

    Modulations of signal transduction and gene expression

    Series series Target Organ Toxicology Series
    Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are direc ... Leer más

    $245.99 USD

  • Audiolibro

    Fire, Burn! & other mysteries

    Four Full-Cast Vintage BBC Radio Dramatisations

    Completo

    2 hora 55 minutos

    Four full-cast stories of suspense from the creator of Dr Gideon FellThe master of the ‘impossible crime’ novel, American author John Dickson Carr was renowned for his Golden Age detective stories featuring the eccentric genius Dr Gideon Fell. This collection brings together four of his captivating radio plays, including a time-slip murder mystery, a chilling supernatural tale, a menacing story of ... Leer más

    $18.99 USD

  • Audiolibro

    Murder International

    Ten Classic Full-Cast BBC Radio Crime Dramas

    Completo

    4 hora 47 minutos

    Ten vintage dramas on the theme of murder, written by internationally recognised authors and set across the globe‘Murder is murder, anywhere in the world. The taking of life, the most terrible crime a human being can commit, is the same in any language, whether it springs from vengeance, greed, hate, love or whatever...’Conceived by BBC World Service producer Derek Hoddinott, the 1976 anthology ... Leer más

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  • Nutrition in Epigenetics

    The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics ... Leer más

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  • Yeast

    Molecular and Cell Biology

    Yeast is one of the oldest domesticated organisms and has both industrial and domestic applications. In addition, it is very widely used as a eukaryotic model organism in biological research and has offered valuable knowledge of genetics and basic cellular processes. In fact, studies in yeast have offered insight in mechanisms underlying ageing and diseases such as Alzheimers, Parkinsons and ... Leer más

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  • HIV-1 Integrase

    Mechanism and Inhibitor Design

    de Binghe Wang ...
    Series Libro 9 - Wiley Series in Drug Discovery and Development
    This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against ... Leer más

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  • Epigenetic Regulation and Epigenomics

    Edición de Robert A. Meyers ...
    Series series Advances in Molecular Biology and Medicine
    Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused ... Leer más

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  • Medicinal Chemistry of Anticancer Drugs

    Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research ... Leer más

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  • The AH Receptor in Biology and Toxicology

    This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this ... Leer más

    $158.00 USD

  • Protein Chaperones and Protection from Neurodegenerative Diseases

    Series Libro 7 - Wiley Series in Protein and Peptide Science
    How protein chaperones protect cells from neurodegenerative diseasesIncluding contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases.Examining how different ... Leer más

    $144.00 USD

  • The DNA Damage Response: Implications on Cancer Formation and Treatment

    Edición de Yosef Shiloh, Kum Kum Khanna ...
    Series series Biomedical and Life Sciences (R0)
    The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living ... Leer más

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  • Mitochondria and Cancer

    Edición de Keshav Singh, Leslie Costello ...
    Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration ... Leer más

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