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    Science, Politics, and the Human Costs of Defeating Disease

    **"A real jewel of science history...brims with suspense and now-forgotten catastrophe and intrigue...Wadman’s smooth prose calmly spins a surpassingly complicated story into a real tour de force."—The New York Times“Riveting . . . [The Vaccine Race] invites comparison with Rebecca Skloot's 2007 The Immortal Life of Henrietta Lacks.”—NatureThe epic and controversial story of a major breakthrough ... Leer más

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  • Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics

    Series series Medicine (R0)
    Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be ... Leer más

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  • Models of Protection Against HIV/SIV

    Models of Protection Against HIV/SIV

    A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying ... Leer más

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  • Systemic Vasculitides: Current Status and Perspectives

    Series series Biomedical and Life Sciences (R0)
    In spite of their relatively low prevalence, systemic vasculitides have been the object of intensive basic and clinical investigations over the last few years. As a consequence, important advancements have been achieved: from updated diagnostic and classification criteria and a more rational nomenclature to the recognition of an expanding spectrum of clinical manifestations and potentially ... Leer más

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  • Crossroads Between Innate and Adaptive Immunity IV

    Series series Biomedical and Life Sciences (R0)
    This volume presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen ... Leer más

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  • Novel Immunotherapeutic Approaches to the Treatment of Cancer

    Drug Development and Clinical Application

    Edición de Paul D. Rennert ...
    Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and ... Leer más

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  • Arachidonate Remodeling and Inflammation

    Series series Progress in Inflammation Research
    Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation ... Leer más

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  • Challenges in Infectious Diseases

    Edición de I.W. Fong ...
    Series series Medicine (R0)
    This next volume in the series will provide up to date Information and discussion on future approach to control several challenging Infectious Disease worldwide. The past decade has been highlighted by numerous advances in research of medical scientific knowledge. medical technology and the biological and diagnostic techniques-but somewhat less dramatic changes or improvement in management of ... Leer más

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  • Novel Strategies in the Design and Production of Vaccines

    Edición de Sara Cohen, Avigdor Shafferman ...
    Series series Biomedical and Life Sciences (R0)
    Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from ... Leer más

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  • Advances in Research on Neurodegeneration

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    We organized the Seventh International Winter Conference on Neurodegeneration and Neuroinflammation in a small town of Karuizawa in Nagano Prefecture in Japan on January 20 to 22, 1999. Karuizawa is a nice summer as well as winter resort close to the place for winter Olympic game in the year of 1998. Over 40 scientists gathered together and made hot discussion. Neurodegeneration and ... Leer más

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