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  • Targeting Undruggable Targets: Protein Degradation (PROTACs), Molecular Glues, and Allosteric Inhibition

    ChaptersChapter 1: Targeting Undruggable Oncogenic Proteins in Women's Cancers: Mechanisms of Protein Degradation via PROTACs and Molecular Glues in Breast and Ovarian MalignanciesChapter 2: Molecular Medicine Approaches in Oncology: Harnessing PROTACs, Molecular Glues, and Allosteric Inhibitors for Precision Targeting of Undruggable Cancer DriversChapter 3: Integrating Artificial Intelligence in ... Leer más

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    Edición de Haleem J. Issaq ...
    Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. ... Leer más

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  • Network Medicine

    Complex Systems in Human Disease and Therapeutics

    Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in ... Leer más

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  • Metabolomics in Practice

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    Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording and evaluating data as well as method validation. By systematically covering the entire workflow, from sample preparation to data processing, the ... Leer más

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  • Rethinking Cancer

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    Series series Vienna Series in Theoretical Biology
    Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been ... Leer más

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  • Metabolomics Perspectives

    From Theory to Practical Application

    Edición de Jacopo Troisi ...
    Metabolomics Perspectives: From Theory to Practical Application is an expertly written volume, which provides a thorough description of the current state-of-the-art in the metabolomics field. The philosophy behind the book is to guide the reader in a step-by-step exploration of metabolomics experiments, ranging from sample preparation to data extraction, analysis and interpretation, and to discuss ... Leer más

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  • NMR Metabolomics in Cancer Research

    Series series Woodhead Publishing Series in Biomedicine
    The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to ... Leer más

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  • Flow Cytometry in Drug Discovery and Development

    Edición de Virginia Litwin, Philip Marder ...
    This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The ... Leer más

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  • Systems Biology in Drug Discovery and Development

    Series Libro 9 - Wiley Series on Technologies for the Pharmaceutical Industry
    The first book to focus on comprehensive systems biology as applied to drug discovery and developmentDrawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent ... Leer más

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  • Systems Biology in Biotech & Pharma

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    Series series Medicine (R0)
    The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial ... Leer más

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  • Computational Toxicology

    Risk Assessment for Chemicals

    Edición de Sean Ekins ...
    Series series Wiley Series on Technologies for the Pharmaceutical Industry
    A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals.Provides a perspective of what is currently achievable with computational toxicology and a view to future developmentsHelps readers overcome questions of data sources, ... Leer más

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  • Targeting Protein-Protein Interactions for Drug Discovery

    Edición de Jian Zhang ...
    Up-to-date reference surveying the latest advances in the structural understanding of protein-protein interactions and developments in drug discovery and therapeuticsTargeting Protein–Protein Interactions for Drug Discovery provides a systematic and comprehensive overview of protein-protein interactions (PPIs), reviewing foundational concepts, advanced methodologies, and emerging therapeutic ... Leer más

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