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Predictive ADMET

Integrated Approaches in Drug Discovery and Development

de Jianling Wang, Laszlo Urban ...

This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward.The book introduces the current clinical practice for ... Leer más

$143.00 USD

This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward.The book introduces the current clinical practice for
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Antitargets and Drug Safety

Edición de Laszlo Urban, Vinod Patel, Roy J. Vaz ...

Series Libro 66 - Methods & Principles in Medicinal Chemistry
With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future.Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, ... Leer más

$151.00 USD

With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future.Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings,
... Leer más
Predictive Toxicology in Drug Safety

Edición de Jinghai J. Xu, Laszlo Urban ...

According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), 'developing new scientific approaches to detecting, understanding, predicting and preventing adverse events' was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the ... Leer más

$131.99 USD

According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), 'developing new scientific approaches to detecting, understanding, predicting and preventing adverse events' was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the
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Specification of Drug Substances and Products

Development and Validation of Analytical Methods

Edición de Thomas W. Rosanske, Christopher M. Riley ...

Specification of Drug Substances and Products: Development and Validation of Analytical Methods is a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development and validation of analytical methods. This book is intended as more than a review of new regional guidelines, existing ... Leer más

$107.99 USD

Specification of Drug Substances and Products: Development and Validation of Analytical Methods is a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development and validation of analytical methods. This book is intended as more than a review of new regional guidelines, existing
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The Creative Destruction of Medicine

How the Digital Revolution Will Create Better Health Care

de Eric Topol ...

**How genomics, big data, and digital technology are revolutionizing every aspect of medicine, from physical exams to drug prescriptions to organ transplants“The Creative Destruction of Medicine should be required reading by all physicians and in all medical schools. It is simply that good.” —Forbes**Technology dominates our lives, and personal genomics is revolutionizing biology. But despite the ... Leer más

$12.99 USD

**How genomics, big data, and digital technology are revolutionizing every aspect of medicine, from physical exams to drug prescriptions to organ transplants“The Creative Destruction of Medicine should be required reading by all physicians and in all medical schools. It is simply that good.” —Forbes**Technology dominates our lives, and personal genomics is revolutionizing biology. But despite the
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Peptide and Protein Interaction with Membrane Systems

Applications to Antimicrobial Therapy and Protein Drug Delivery

de Sara Bobone ...

Series series Chemistry and Material Science (R0)
In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their ... Leer más

$89.99 USD

In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their
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Understanding Prescription Drugs For Canadians For Dummies

de Heather McDonald-Blumer MD, Ian Blumer ...

The ultimate Canadian guide to prescription medicationOver half of all Canadians take at least one prescription drug, but most of us know very little about the medication we're taking, including why we've been prescribed anything in the first place. Understanding Prescription Drugs Canadians For Dummies will answer many of the questions Canadians have about prescription drugs, but were afraid ask ... Leer más

$16.99 USD

The ultimate Canadian guide to prescription medicationOver half of all Canadians take at least one prescription drug, but most of us know very little about the medication we're taking, including why we've been prescribed anything in the first place. Understanding Prescription Drugs Canadians For Dummies will answer many of the questions Canadians have about prescription drugs, but were afraid ask
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Drug Discovery Toxicology

From Target Assessment to Translational Biomarkers

Edición de J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy, Yvonne Will ...

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process.• Guides researchers as to what drug safety experiments are both practical and useful• Covers a variety of key topics – safety lead optimization, in vitro-in vivo ... Leer más

$181.00 USD

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process.• Guides researchers as to what drug safety experiments are both practical and useful• Covers a variety of key topics – safety lead optimization, in vitro-in vivo
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Drug Dealer, MD

How Doctors Were Duped, Patients Got Hooked, and Why It’s So Hard to Stop

de Anna Lembke ...

The disturbing connection between well-meaning physicians and the prescription drug epidemic.Three out of four people addicted to heroin probably started on a prescription opioid, according to the director of the Centers for Disease Control and Prevention. In the United States alone, 16,000 people die each year as a result of prescription opioid overdose. But perhaps the most frightening aspect of ... Leer más

$16.99 USD

The disturbing connection between well-meaning physicians and the prescription drug epidemic.Three out of four people addicted to heroin probably started on a prescription opioid, according to the director of the Centers for Disease Control and Prevention. In the United States alone, 16,000 people die each year as a result of prescription opioid overdose. But perhaps the most frightening aspect of
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Using Animal Models In Biomedical Research: A Primer For The Investigator

de Pierce K H Chow, Robert T H Ng, Bryan E Ogden ...

Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. Such in vivo modes are especially important in proof-of-principle experiments and in establishing the preclinical safety and efficacy data required for progressing to human clinical trials. A practical understanding of the choice, care and use of animal models is thus expected and ... Leer más

$44.99 USD

Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. Such in vivo modes are especially important in proof-of-principle experiments and in establishing the preclinical safety and efficacy data required for progressing to human clinical trials. A practical understanding of the choice, care and use of animal models is thus expected and
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High-Throughput Screening Methods in Toxicity Testing

Edición de Pablo Steinberg ...

Explores the benefits and limitations of the latest high-throughput screening methodsWith its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by ... Leer más

$152.00 USD

Explores the benefits and limitations of the latest high-throughput screening methodsWith its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by
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Oral Formulation Roadmap from Early Drug Discovery to Development

Edición de Elizabeth Kwong ...

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development.• Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry• Focuses on pre (or non-) clinical and early ... Leer más

$138.00 USD

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development.• Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry• Focuses on pre (or non-) clinical and early
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Methods & Principles in Medicinal Chemistry

Predictive ADMET

Antitargets and Drug Safety

Predictive Toxicology in Drug Safety

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Specification of Drug Substances and Products

The Creative Destruction of Medicine

Peptide and Protein Interaction with Membrane Systems

Understanding Prescription Drugs For Canadians For Dummies

Drug Discovery Toxicology

Drug Dealer, MD

Using Animal Models In Biomedical Research: A Primer For The Investigator

High-Throughput Screening Methods in Toxicity Testing

Oral Formulation Roadmap from Early Drug Discovery to Development

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