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  • Cholesterol Explained: Understanding The Science, Significance, Tests, Management Options, and Controversies

    Cholesterol Explained offers clear, compassionate, and science-based guidance to help readers understand cholesterol, interpret test results, and navigate treatment options - from medications to lifestyle changes - in a simple yet accurate way. Written by two leading Australian cardiologists, it dispels myths, clarifies controversies, and presents evidence in a practical, accessible style to ... Leer más

    $9.99 USD

  • Lipoprotein(a)

    Series series Medicine (R0)
    Lipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease. Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still ... Leer más

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    Biology and Pathobiology

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  • Tumor Microenvironment

    Edición de Dietmar W. Siemann ...
    The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have ... Leer más

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  • Hyaluronan in Cancer Biology

    Edición de Robert Stern ...
    Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells ... Leer más

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  • Analogue-based Drug Discovery II

    Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog ... Leer más

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  • Recombinant Antibodies for Immunotherapy

    Edición de Melvyn Little, PhD ...
    Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, 'arming' mAbs, novel alternative Ab constructs, ... Leer más

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  • Novel Developments in Stem Cell Mobilization

    Focus on CXCR4

    Series series Biomedical and Life Sciences (R0)
    Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell ... Leer más

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  • Fusion Protein Technologies for Biopharmaceuticals

    Applications and Challenges

    Edición de Stefan R. Schmidt ...
    The state of the art in biopharmaceutical FUSION PROTEIN DESIGNFusion proteins belong to the most lucrative biotech drugs-with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the ... Leer más

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  • Glioblastoma:

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    Edición de Swapan K. Ray ...
    Series series Biomedical and Life Sciences (R0)
    Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is ... Leer más

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  • Targeted Therapy in Translational Cancer Research

    Series series Translational Oncology
    Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy ... Leer más

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  • Renal Cell Carcinoma

    Translational Biology, Personalized Medicine, and Novel Therapeutic Targets

    Series series Biomedical and Life Sciences (R0)
    This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma. ... Leer más

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