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  • Concepts and Case Studies in Chemical Biology

    Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years.Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well ... Leer más

    $85.00 USD

  • Small Molecule — Protein Interactions

    Edición de Herbert Waldmann, Marcus Koppitz ...
    Series series Medicine (R0)
    Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters ... Leer más

    $89.99 USD

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  • New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

    Series series Medicine (R0)
    From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the ... Leer más

    $89.09 USD

  • Tissue-Specific Estrogen Action

    Novel Mechanisms, Novel Ligands, Novel Therapies

    Series series Springer Nature Proceedings excluding Computer Science
    Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the ... Leer más

    $143.09 USD

  • Trichloroethylene: Toxicity and Health Risks

    Series series Molecular and Integrative Toxicology
    A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways ... Leer más

    $143.99 USD

  • Advances in Mitochondrial Medicine

    Series series Biomedical and Life Sciences (R0)
    Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox ... Leer más

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  • Fluorescent Proteins I

    From Understanding to Design

    Edición de Gregor Jung ...
    Series series Chemistry and Material Science (R0)
    Fluorescent proteins are intimately connected to research in the life sciences. Tagging of gene products with fluorescent proteins has revolutionized all areas of biosciences, ranging from fundamental biochemistry to clinical oncology, to environmental research. The discovery of the Green Fluorescent Protein, its first, seminal application and the ingenious development of a broad palette of ... Leer más

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  • High Throughput Screening for Novel Anti-Inflammatories

    Edición de Michael Kahn ...
    Series series Progress in Inflammation Research
    Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent ... Leer más

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  • Nanomedicine

    Principles and Perspectives

    Series series Chemistry and Material Science (R0)
    Increasing demand for and awareness of the applications of nanotechnology in medicine has resulted in the emergence of a new fast-growing multidisciplinary area - nanomedicine. This book offers comprehensive knowledge of and diverse perspectives on nanomedicine through two independent volumes. It aims to bridge the gap between nanotechnology and medicine through contributions by world-renowned ... Leer más

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  • Resistance to Aromatase Inhibitors in Breast Cancer

    Edición de Alexey Larionov ...
    Series series Biomedical and Life Sciences (R0)
    Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically ... Leer más

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  • Therapeutic Vaccination Strategies

    Edición de P. Walden, W. Sterry, H. Hennekes ...
    Series series Medicine (R0)
    The induction of immune responses against tumor cells by vaccination is rapidly evolving as a therapeutic modality with new potentials for the treatment of cancer. It is based on the fact that our immune system can identify tumor cells and, once activated, is capable of developing specific immunity against the neoplastic cells. Numerous observations and intense research clearly document the major ... Leer más

    $49.99 USD