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    The book covers the functional significance and properties of erythrocytes, their generation, senescence, and suicidal death. It further summarizes knowledge about hormones influencing erythrocyte formation including erythropoietin as well as disorders affecting and involving erythrocytes such as anemia, malaria, and sepsis.This seminal work forms a unique reference on the most abundant cell type ... Leer más

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  • Antiviral Drugs

    From Basic Discovery Through Clinical Trials

    This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the ... Leer más

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  • Antibiotics

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    Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic ... Leer más

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  • Viral Proteases and Their Inhibitors

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    Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and ... Leer más

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  • Moonlighting Cell Stress Proteins in Microbial Infections

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    Series series Biomedical and Life Sciences (R0)
    Microbial infection is increasingly seen as a problem as we begin to run out of antibiotics. Understanding how microbes cause disease is essential. In recent years it has begun to emerge that bacteria, fungi, protozoa and viruses can use their cell stress proteins to cause infection. This volume brings together the world's leading experts in the study of the microbial and human cell stress ... Leer más

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  • Emerging Cancer Therapy

    Microbial Approaches and Biotechnological Tools

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    Series Libro 50 - Methods & Principles in Medicinal Chemistry
    By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses.It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, ... Leer más

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  • Advances in Enzymology and Related Areas of Molecular Biology, Volume 77

    Edición de Eric J. Toone ...
    Series Libro 238 - Advances in Enzymology and Related Areas of Molecular Biology
    This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. ... Leer más

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  • Adult Stem Cells

    Edición de Kursad Turksen ...
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    Adult Stem Cells, second edition, takes a critical look at issues concerning the developmental or differentiation potential for a variety of tissue types and for specific adult stem cell types. Since the first edition appeared a decade ago, our understanding of adult stem cells, and more specifically tissue-specific adult stem cells, has advanced tremendously. And an increased interest in ... Leer más

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