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  • TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

    Edited by Robert Amson, Adam Telerman ...
    Series series Biomedical and Life Sciences (R0)
    This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and ... Read more

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  • DNA Repair of Cancer Stem Cells

    Series series Biomedical and Life Sciences (R0)
    The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, ... Read more

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  • Enzymology Primer for Recombinant DNA Technology

    Enzymes are indispensable tools in recombinant DNA technology and genetic engineering. This book not only provides information for enzymologists, but does so in a manner that will also aid nonenymologists in making proper use of these biocatalysts in their research. The Enzymology Primer for Recombinant DNA Technology includes information not usually found in the brief descriptions given in most ... Read more

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    Protein Transcription is a key element of cellular and organ regulation. Proteins in Eukaryotic Transcription covers structure and function of all major elements associated with transcription. - Mechanism of RNA polymerase I Transcription - Structure and function of RNA Polymerase II - Structure and function of the TFIID complex - Functional properties of Chromatin Remodeling Enzymes - ... Read more

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  • Cilia

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    The scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling ... Read more

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  • Nuclear Reprogramming and Stem Cells

    Series series Stem Cell Biology and Regenerative Medicine
    Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states. Importantly, in addition to offering the opportunity to delve deeply into the mechanisms that drive disease aetiology the research is realistically opening the doors for development of ... Read more

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  • Hypoxia and Cancer

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    Series series Biomedical and Life Sciences (R0)
    The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the ... Read more

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  • Human iPS Cells in Disease Modelling

    Edited by Keiichi Fukuda ...
    Series series Biomedical and Life Sciences (R0)
    Human iPS cells have a great potential to be cell sources for regenerative medicine because of the promise of infinite self-renewal and the capability to differentiate into multiple cell types. This book focuses on another great potential of human iPS cells, which is the establishment of human disease models using patient-specific iPS cells. Human iPS cells can be easily obtained from a patient’s ... Read more

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  • Endogenous Stem Cell-Based Brain Remodeling in Mammals

    Series series Stem Cell Biology and Regenerative Medicine
    This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our ... Read more

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  • Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation

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