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  • Resistance to Proteasome Inhibitors in Cancer

    Molecular Mechanisms and Strategies to Overcome Resistance

    Edited by Q. Ping Dou ...
    Series series Biomedical and Life Sciences (R0)
    The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature ... Read more

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    Pathophysiology, Pharmacology and Therapeutics: an Update

    Series series Biomedical and Life Sciences (R0)
    This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is ... Read more

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  • Anticancer Genes

    Edited by Stefan Grimm ...
    Series series Biomedical and Life Sciences (R0)
    This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application.Anticancer Genes provides an overview of this nascent field, its genesis, ... Read more

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  • Arterial Chemoreceptors in Physiology and Pathophysiology

    Series series Biomedical and Life Sciences (R0)
    Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds ... Read more

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  • Therapeutic Vaccination Strategies

    Edited by P. Walden, W. Sterry, H. Hennekes ...
    Series series Medicine (R0)
    The induction of immune responses against tumor cells by vaccination is rapidly evolving as a therapeutic modality with new potentials for the treatment of cancer. It is based on the fact that our immune system can identify tumor cells and, once activated, is capable of developing specific immunity against the neoplastic cells. Numerous observations and intense research clearly document the major ... Read more

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  • High Throughput Screening for Novel Anti-Inflammatories

    Edited by Michael Kahn ...
    Series series Progress in Inflammation Research
    Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent ... Read more

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    Edited by Evandro Fei Fang, Tzi Bun Ng ...
    Series series Biomedical and Life Sciences (R0)
    The modern unhealthy diet and lifestyle in conjunction with pathogens, environmental carcinogens and multiple other risk factors increase humans’ susceptibility to different diseases exemplified by elevated levels of cancers, cardiovascular and communicable diseases. Screening of potential drugs from medicinal plants and animals provides a promising strategy for the alleviation of the impact of ... Read more

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    by Ming D. Li ...
    Series series Biomedical and Life Sciences (R0)
    This book provides the most recent knowledge on almost all key aspects of the health impact of tobacco smoking. Its 21 chapters focus on both preclinical and clinical studies. The contents are broad, covering the epidemiology of tobacco smoking; genetic epidemiology; identification of susceptibility genomic regions, genes, and pathways as determined by both human and animal studies; evolutionary ... Read more

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    Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the ... Read more

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  • Resistance to Aromatase Inhibitors in Breast Cancer

    Edited by Alexey Larionov ...
    Series series Biomedical and Life Sciences (R0)
    Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically ... Read more

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  • Novel Approaches to Treatment of Osteoporosis

    Series series Medicine (R0)
    Osteoporosis affects a growing number of the population. Current treatments are based on prevention of further bone loss after the condition is diagnosed, often because a fracture has occurred. Treatments in the future will aim at healing osteoporosis by improving bone mass and quality. This book describes novel discoveries and research which will allow bone to be restored after it has been lost. ... Read more

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