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  • Histone Mutations and Cancer

    Edited by Dong Fang, Junhong Han ...
    Series series Biomedical and Life Sciences (R0)
    This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant ... Read more

    $89.09 USD

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  • Peptide-based Drug Discovery

    Challenges and New Therapeutics

    Edited by Ved Srivastava ...
    Series Book 59 - Drug Discovery Series
    With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies.What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What ... Read more

    $225.89 USD

  • Pharmacogenomics of Human Drug Transporters

    Clinical Impacts

    Sets the foundation for safer, more effective drug therapiesWith this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse ... Read more

    $148.00 USD

  • DNA Repair of Cancer Stem Cells

    Series series Biomedical and Life Sciences (R0)
    The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, ... Read more

    $143.09 USD

  • Macropinocytosis

    Functions and Mechanisms

    Edited by Cosimo Commisso ...
    Series series Biomedical and Life Sciences (R0)
    This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process.Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen ... Read more

    $152.09 USD

  • RNA Damage and Repair

    Edited by Ioly Kotta-Loizou ...
    Series series Biomedical and Life Sciences (R0)
    Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression.However, RNA-based enzymes, ... Read more

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  • Long Noncoding RNA

    Mechanistic Insights and Roles in Inflammation

    Edited by Susan Carpenter ...
    Series series Biomedical and Life Sciences (R0)
    This book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to ... Read more

    $170.09 USD

  • Cancer Stem Cell Markers and Related Network Pathways

    Edited by Shihori Tanabe ...
    Series series Biomedical and Life Sciences (R0)
    This book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype.This book covers various aspects of the molecular networks related to CSCs including ... Read more

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  • Ferroptosis: Mechanism and Diseases

    Series series Biomedical and Life Sciences (R0)
    This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ... Read more

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  • Targets of Cancer Diagnosis and Treatment

    Ion Transport in Tumor Biology

    Series series Biomedical and Life Sciences (R0)
    This third and final volume in the "Ion Transport in Tumor Biology" collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic ... Read more

    $134.09 USD

  • Autophagy in Stem Cell Maintenance and Differentiation

    Series series Biomedical and Life Sciences (R0)
    This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to ... Read more

    $170.09 USD

  • Mortalin Biology: Life, Stress and Death

    Edited by Sunil C. Kaul, Renu Wadhwa ...
    Series series Biomedical and Life Sciences (R0)
    The phrase “Life, stress and death” connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume “Mortalin Biology: Life, Stress and Death” is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it ... Read more

    $143.09 USD