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Showing 1 - 12 of 22 results for “gerd folkers”
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  • Animal Models for Human Cancer

    Discovery and Development of Novel Therapeutics

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results.Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the ... Read more

    $129.00 USD

  • Lead Generation

    Methods and Strategies

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the ... Read more

    $275.00 USD

  • Fragment-based Drug Discovery

    Lessons and Outlook

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed ... Read more

    $151.00 USD

  • Transporters as Drug Targets

    by Raimund Mannhold, Gerd Folkers, Helmut Buschmann ...
    Series series Methods & Principles in Medicinal Chemistry
    As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug ... Read more

    $151.00 USD

  • Protein Therapeutics

    by Raimund Mannhold, Gerd Folkers, Helmut Buschmann ...
    Series series Methods & Principles in Medicinal Chemistry
    In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades.Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, ... Read more

    $282.00 USD

  • Thermodynamics and Kinetics of Drug Binding

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects.Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and ... Read more

    $151.00 USD

  • Data Mining in Drug Discovery

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 57 - Methods & Principles in Medicinal Chemistry
    Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data sources available, both commercial and non ... Read more

    $141.00 USD

  • Microwaves in Organic and Medicinal Chemistry

    by C. Oliver Kappe, Alexander Stadler, Doris Dallinger, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 52 - Methods & Principles in Medicinal Chemistry
    Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed,almost doubling the amount of chemical information with an additional volume.As in the predecessor, a short introductory section covers the theoretical background and evaluates currently available instrumentation andequipment. The main part of the book then ... Read more

    $170.00 USD

  • Drug Metabolism Prediction

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 63 - Methods & Principles in Medicinal Chemistry
    The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists.The authors provide more than a systematic overview of computational tools and knowledge bases for drug metabolism research and their underlying principles. They aim to convey their expert knowledge distilled from many years of experience in the field. In addition to the ... Read more

    $148.00 USD

  • Predictive Toxicology

    From Vision to Reality

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 64 - Methods & Principles in Medicinal Chemistry
    Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment.With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical ... Read more

    $151.00 USD

  • Phosphodiesterases and Their Inhibitors

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 61 - Methods & Principles in Medicinal Chemistry
    Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug.Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, ... Read more

    $142.00 USD

  • In vivo Models for Drug Discovery

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 62 - Methods & Principles in Medicinal Chemistry
    This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases.Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development ... Read more

    $134.00 USD