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Showing 1 - 12 of 22 results for “gerd folkers”
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  • Transporters as Drug Targets

    by Raimund Mannhold, Gerd Folkers, Helmut Buschmann ...
    Series series Methods & Principles in Medicinal Chemistry
    As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug ... Read more

    $151.00 USD

  • Predictive Toxicology

    From Vision to Reality

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 64 - Methods & Principles in Medicinal Chemistry
    Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment.With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical ... Read more

    $151.00 USD

  • Protein-Protein Interactions in Drug Discovery

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 56 - Methods & Principles in Medicinal Chemistry
    Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as ... Read more

    $160.00 USD

  • Lead Generation

    Methods and Strategies

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the ... Read more

    $275.00 USD

  • Thermodynamics and Kinetics of Drug Binding

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects.Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and ... Read more

    $151.00 USD

  • Scaffold Hopping in Medicinal Chemistry

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 58 - Methods & Principles in Medicinal Chemistry
    This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part ... Read more

    $126.00 USD

  • In vivo Models for Drug Discovery

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 62 - Methods & Principles in Medicinal Chemistry
    This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases.Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development ... Read more

    $134.00 USD

  • Bioisosteres in Medicinal Chemistry

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 54 - Methods & Principles in Medicinal Chemistry
    Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions ... Read more

    $148.00 USD

  • Fragment-based Drug Discovery

    Lessons and Outlook

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed ... Read more

    $151.00 USD

  • Drug Metabolism Prediction

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 63 - Methods & Principles in Medicinal Chemistry
    The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists.The authors provide more than a systematic overview of computational tools and knowledge bases for drug metabolism research and their underlying principles. They aim to convey their expert knowledge distilled from many years of experience in the field. In addition to the ... Read more

    $148.00 USD

  • Natural Products in Medicinal Chemistry

    by Hugo Kubinyi, Gerd Folkers, Raimund Mannhold ...
    Series Book 60 - Methods & Principles in Medicinal Chemistry
    The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters.Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new ... Read more

    $146.00 USD

  • Medicinal Chemistry Approaches to Personalized Medicine

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 59 - Methods & Principles in Medicinal Chemistry
    Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues.Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities ... Read more

    $126.00 USD