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Showing 1 - 12 of 12 results for “dennis a smith”
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  • Metabolite Safety in Drug Development

    Edited by Suzanne L. Iverson, Dennis A. Smith ...
    A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA.• Reviews the analytical techniques and experimental designs critical for metabolite ... Read more

    $181.00 USD

  • Attrition in the Pharmaceutical Industry

    Reasons, Implications, and Pathways Forward

    by Alexander Alex, C. John Harris, Dennis A. Smith ...
    With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency.Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attritionTackles a problem that adds billions of ... Read more

    $126.00 USD

  • Pharmacokinetics and Metabolism in Drug Design

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 51 - Methods & Principles in Medicinal Chemistry
    In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug ... Read more

    $125.00 USD

  • Reactive Drug Metabolites

    by Deepak Dalvie, R. Scott Obach, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Dennis A. Smith, Amit S. Kalgutkar ...
    Series Book 55 - Methods & Principles in Medicinal Chemistry
    Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone ... Read more

    $150.00 USD

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  • Antibiotics and Antibiotic Resistance

    by Ola Sköld ...
    This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight ... Read more

    $52.00 USD

  • High-Throughput Screening Methods in Toxicity Testing

    Edited by Pablo Steinberg ...
    Explores the benefits and limitations of the latest high-throughput screening methodsWith its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by ... Read more

    $152.00 USD

  • Oral Formulation Roadmap from Early Drug Discovery to Development

    Edited by Elizabeth Kwong ...
    Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development.• Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry• Focuses on pre (or non-) clinical and early ... Read more

    $138.00 USD

  • Oral Bioavailability Assessment

    Basics and Strategies for Drug Discovery and Development

    by Ayman F. El-Kattan, Mike S. Lee ...
    Series series Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
    Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability• Helps readers reduce the failure rate of drug ... Read more

    $155.00 USD

  • ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

    Applications in Drug Discovery and Development

    by Honghui Zhou, Frank-Peter Theil ...
    With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugsCombines theoretical with practical aspects of ADME in ... Read more

    $133.00 USD

  • Enzyme- and Transporter-Based Drug-Drug Interactions

    Progress and Future Challenges

    Edited by K. Sandy Pang, A. David Rodrigues, Raimund M. Peter ...
    Series series Biomedical and Life Sciences (R0)
    Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area ... Read more

    $188.09 USD

  • Predictive ADMET

    Integrated Approaches in Drug Discovery and Development

    by Jianling Wang, Laszlo Urban ...
    This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward.The book introduces the current clinical practice for ... Read more

    $143.00 USD

  • From Artemisia annua L. to Artemisinins

    The Discovery and Development of Artemisinins and Antimalarial Agents

    by Youyou Tu ...
    From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of ... Read more

    $134.99 USD