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  • Reactive Drug Metabolites

    Series Book 55 - Methods & Principles in Medicinal Chemistry
    Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone ... Read more

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  • Drug Information: A Guide for Pharmacists, Sixth Edition

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  • Aggregation of Therapeutic Proteins

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  • Biological Drug Products

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    Edited by Wei Wang, Manmohan Singh ...
    Tested and proven solutions to the challenges of biological drug product developmentBiological drug products play a central role in combating human diseases; however, developing new successful biological drugs presents many challenges, including labor intensive production processes, tighter regulatory controls, and increased market competition. This book reviews the current state of the science, ... Read more

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  • Next Generation Antidepressants

    Moving Beyond Monoamines to Discover Novel Treatment Strategies for Mood Disorders

    The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new ... Read more

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  • Process Scale Purification of Antibodies

    Edited by Uwe Gottschalk ...
    Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification.• Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and ... Read more

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  • Prescriber's Guide: Antidepressants

    Stahl's Essential Psychopharmacology

    This spin-off from Stephen M. Stahl's new, completely revised, and fully updated sixth edition of the Prescriber's Guide covers the most important drugs in use today for treating depression. Now established as the indispensable formulary in psychopharmacology, easy to navigate and easy to use, the Prescriber's Guide combines evidence-based information with clinically informed guidance to support ... Read more

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  • Mechanisms and Models in Rheumatoid Arthritis

    Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this ... Read more

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  • Treatment of Cystic Fibrosis and Other Rare Lung Diseases

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    This volume describes the pathogenesis and pathophysiology of several pulmonary diseases as well as their treatment. It also discusses the underlying genetic and molecular biological basis, which opens the way for new treatments for these conditions.It focuses on the treatment of cystic fibrosis including CFTR (cystic fibrosis transmembrane-conductance regulator) modulator therapies, drug ... Read more

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  • Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders

    Edited by Nicola Brunetti-Pierri ...
    Series series Biomedical and Life Sciences (R0)
    In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to ... Read more

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