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  • Chromosome Abnormalities and Genetic Counseling

    Series series Oxford Monographs on Medical Genetics
    Even as classic cytogenetics has given way to molecular karyotyping, and as new deletion and duplication syndromes are identified almost every day, the fundamental role of the genetics clinic remains mostly unchanged. Genetic counselors and medical geneticists explain the "unexplainable," helping families understand why abnormalities occur and whether they're likely to occur again. Chromosome ... Read more

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  • The Age of Genomes

    Tales from the Front Lines of Genetic Medicine

    A leading geneticist explores what promises to be one of the most transformative advances in health and medicine in historyAlmost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet, while the plummeting cost of DNA sequencing makes it increasingly ... Read more

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  • Molecular Genetics of Inflammatory Bowel Disease

    Edited by Mauro D'Amato, John D Rioux ...
    Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on ... Read more

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  • Site-directed insertion of transgenes

    Series Book 23 - Topics in Current Genetics
    The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in ... Read more

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  • Point of Care Medicine

    An ultra-concise, evidence-based guide to the initial patient encounterPoint of Care Medicine delivers the most patient-care information in the least amount of words possible. Within its pages you will find the evidence-based information necessary to immediately manage the most common problems occurring in hospitalized adult patients--ranging from chest pain and renal failure to anemia and ... Read more

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  • The Science of Human Perfection: How Genes Became the Heart of American Medicine

    Almost daily we hear news stories, advertisements, and scientific reports that promise genetic medicine will make us live longer, enable doctors to identify and treat diseases before they start, and individualize our medical care. But surprisingly, a century ago eugenicists were making the same promises. The Science of Human Perfection traces the history of the promises of medical genetics and of ... Read more

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  • RNA Metabolism in Trypanosomes

    Edited by Albrecht Bindereif ...
    Series Book 28 - Nucleic Acids and Molecular Biology
    Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene ... Read more

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  • Regulating Pre-Implantation Genetic Diagnosis

    A Comparative and Theoretical Analysis

    Series series Biomedical Law and Ethics Library
    The successful achievement of pregnancies following pre-implantation genetic diagnosis (PGD) was first reported in April 1990. The technology is often used for patients who are at substantial risk of conceiving a pregnancy affected by a known genetic disorder, however from this technology other more controversial uses have arisen such as HLA typing to save the life of a sibling, gender selection ... Read more

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  • The Neurobiology and Genetics of Nicotine and Tobacco

    Series series Biomedical and Life Sciences (R0)
    The primary purpose of this book and its companion volume The Neuropharmacology of Nicotine Dependence is to explore the ways in which recent studies on nicotine and its role in tobacco addiction have opened our eyes to the psychopharmacological properties of this unique and fascinating drug. While the present volume considers the molecular and genetic factors which influence behavioral responses ... Read more

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  • Regulatory Networks in Stem Cells

    Edited by Vinagolu K. Rajasekhar ...
    Series series Biomedical and Life Sciences (R0)
    Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, ... Read more

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  • The Functional Nucleus

    This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of ... Read more

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