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  • The Future of HIV-1 Therapeutics

    Resistance Is Futile?

    Series series Biomedical and Life Sciences (R0)
    This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of ... Read more

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    Science, Politics, and the Human Costs of Defeating Disease

    **"A real jewel of science history...brims with suspense and now-forgotten catastrophe and intrigue...Wadman’s smooth prose calmly spins a surpassingly complicated story into a real tour de force."—The New York Times“Riveting . . . [The Vaccine Race] invites comparison with Rebecca Skloot's 2007 The Immortal Life of Henrietta Lacks.”—NatureThe epic and controversial story of a major breakthrough ... Read more

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  • Antimicrobial Therapy Guide®, 19th edition

    The leading clinical reference source on therapeutic antimicrobials, this latest edition contains up-to-date treatment guidelines and algorithms for most infections in an expanded, easy-to-read format. Composed by a team of expert contributing editors, this book is conveniently organized and tabbed for quick reference of drug toxicities, prophylaxis strategies, and dosage options. Now available ... Read more

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  • Parasitología Médica

    Los parásitos son organismos ominipresentes quienes, desde tiempos históricos, han sido asociados como causales de enfermedades de magnitud diversa llegando incluso a generar epidemias y pandemias. Hoy en día, algunas parasitosis constituyen aún problemas importantes de salud como el dengue y la malaria. Debido a las características de transmisibilidad y patogenicidad de las parasitosis, las ... Read more

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  • Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics

    Series series Medicine (R0)
    Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be ... Read more

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  • Crossroads Between Innate and Adaptive Immunity IV

    Series series Biomedical and Life Sciences (R0)
    This volume presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen ... Read more

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  • Chemokine Receptors and NeuroAIDS

    Beyond Co-Receptor Function and Links to Other Neuropathologies

    Edited by Olimpia Meucci ...
    Series series Biomedical and Life Sciences (R0)
    Chemokine Receptors and NeuroAIDS: Beyond the Co-receptor Function and Links to Other Neuropathologies focuses on unresolved or emerging issues concerning the role of chemokine receptors in neuronal injury and HIV neuropathology, including their ability to regulate fundamental neuronal and glial functions and their role in neurovirulence and neurotoxicity. Although the importance of these ... Read more

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  • Novel Strategies in the Design and Production of Vaccines

    Series series Biomedical and Life Sciences (R0)
    Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from ... Read more

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  • Modern Vaccinology

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    The recent developments in modern vaccinology are mainly based on: (i) cloning of microbial genes into recombinant vectors containing genetic information for expression of desired neutralizing immunogens; (ii) alternatives of attenuated vectors with deleted genes permitting the insertion of several foreign genes expressing antigens exposed to the host immune system during the abortive replication ... Read more

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  • Current Topics in Innate Immunity II

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    Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may ... Read more

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  • Uptake and Trafficking of Protein Toxins

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    Series series Biomedical and Life Sciences (R0)
    This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary ... Read more

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