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Showing 1 - 12 of 12 results for “bart vanhaesebroeck”
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  • Phosphoinositide 3-kinase in Health and Disease

    Volume 2

    Edited by Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt ...
    Series Book 347 - Current Topics in Microbiology and Immunology
    PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the ... Read more

    $188.09 USD

  • Phosphoinositide 3-kinase in Health and Disease

    Volume 1

    Edited by Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt ...
    Series Book 346 - Current Topics in Microbiology and Immunology
    From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and ... Read more

    $188.99 USD

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  • Handbook of Cell Signaling

    Edited by Ralph A. Bradshaw, Edward A. Dennis ...
    Series series Cell Biology
    Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular ... Read more

    $481.49 USD

  • Targeting Protein Kinases for Cancer Therapy

    by David J. Matthews, Mary E. Gerritsen ...
    An expert guide to targeting protein kinases in cancer therapyResearch has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication.Complete ... Read more

    $148.00 USD

  • Anticancer Drug Development

    Edited by Bruce C. Baguley, David J. Kerr ...
    Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and ... Read more

    $161.99 USD

  • Resistance of Cancer Cells to CTL-Mediated Immunotherapy

    Edited by Benjamin Bonavida, Salem Chouaib ...
    Series series Biomedical and Life Sciences (R0)
    This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, ... Read more

    $89.09 USD

  • miRNA Regulation of the Translational Machinery

    Edited by Robert E. Rhoads ...
    Series series Biomedical and Life Sciences (R0)

    $89.09 USD

  • Advances in Biology and Therapy of Multiple Myeloma

    Volume 1: Basic Science

    Edited by Nikhil C. Munshi, Kenneth C. Anderson ...
    Series series Biomedical and Life Sciences (R0)
    Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to ... Read more

    $143.09 USD

  • The Inhibitor Index

    A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads

    by Daniel Purich ...
    Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to ... Read more

    $305.00 USD

  • Cellular and Molecular Mechanisms of Inflammation

    Receptors of Inflammatory Cells: Structure—Function Relationships

    Edited by Charles G. Cochrane, Michael A. Gimbrone ...
    Receptors of Inflammatory Cells: Structure-Function Relationships is the first in a new serial on Cellular and Molecular Mechanisms of Inflammation. The purpose of this serial is to bring together the latest knowledge in various areas of research in this actively developing field around a topical focus. These volumes are not intended to present comprehensive reviews. Rather, each contribution is ... Read more

    $65.69 USD

  • Pharmacogenomics of Human Drug Transporters

    Clinical Impacts

    by Toshihisa Ishikawa, Richard B. Kim, Jörg König ...
    Sets the foundation for safer, more effective drug therapiesWith this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse ... Read more

    $148.00 USD

  • PI3K-mTOR in Cancer and Cancer Therapy

    Edited by Nandini Dey, Pradip De, Brian Leyland-Jones ...
    Series series Medicine (R0)
    In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR ... Read more

    $143.09 USD