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  • Annual, Lunar, and Tidal Clocks

    Patterns and Mechanisms of Nature's Enigmatic Rhythms

    Edited by Hideharu Numata, Barbara Helm ...
    Series series Biomedical and Life Sciences (R0)
    There is more to biological rhythms than circadian clocks. This book aims at promoting the exciting potential of a deeper understanding of circannual, circatidal, and circalunar clocks. It highlights new developments, summarizes existing knowledge, and integrates different perspectives with the tools and ideas of diverse fields of current biology.For predominantly pragmatic reasons, research in ... Read more

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    Series series Medicine (R0)
    This first volume in a projected series contains the proceedings of the first of the Keio University International Symposia for Life Sciences and Medicine under the sponsorship of the Keio University Medical Science Fund. As stated in the address by the President of Keio University at the opening of the 1996 symposium, the fund of Dr. Mitsunada Sakaguchi. The Keio was established by the generous ... Read more

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  • Astrocytes in (Patho)Physiology of the Nervous System

    Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately ... Read more

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  • Müller Cells in the Healthy and Diseased Retina

    Series series Biomedical and Life Sciences (R0)
    Müller cells may be used in the future for novel therapeutic strategies to protect neurons against apoptosis (for example, somatic gene therapy), or to differentiate retinal neurons from Müller/stem cells. Meanwhile, a proper understanding of the gliotic responses of Müller cells in the diseased retina, and of their protective vs. detrimental effects, is essential for the development of efficient ... Read more

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  • Folding for the Synapse

    Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an ... Read more

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  • Growth Hormone II

    Basic and Clinical Aspects

    Series series Serono Symposia USA
    This book is a compendium of proceedings from the Symposium on Growth Hormone II: Basic and Clinical Aspects. The intent of the sym posium was to review current aspects of the rapidly expanding science of growth hormone (GH) neuroendocrinology, especially those develop ments that occurred since our last meeting in 1985. The meeting was timely since there have been many new and exciting ... Read more

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  • Development of the Rat Spinal Cord: Immuno- and Enzyme Histochemical Approaches

    Series Book 129 - Advances in Anatomy, Embryology and Cell Biology
    The studies described here were carried out in the Neuroregul ation Group, Department of Physiology, University of Leiden, the Netherlands. Over the last decade, this group, in close collaboration with the Department of Neurosurgery of the Academic Hospital of Leiden, has studied the development of the central nervous system from a neuroanatomical as well as a clinical perspective. During this ... Read more

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  • The Cadherin Superfamily

    Key Regulators of Animal Development and Physiology

    Series series Biomedical and Life Sciences (R0)
    This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the ... Read more

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  • Neurogenesis in the Adult Brain I

    Neurobiology

    Series series Biomedical and Life Sciences (R0)
    The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline ... Read more

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  • The Catecholaminergic Innervation of the Rat Amygdala

    by Esther Asan ...
    Series Book 142 - Advances in Anatomy, Embryology and Cell Biology
    Experimental evidence indicated that catecholamines are able to modulate information processing in the amygdaloid complex. The present study provides a detailed documentation of ultrastructural and neurochmical characteristics of dopaminergic, noradrinergic, and adrenergic afferent fibers and of their target structures in central, basal and intercalated amygdaloid nuclei. ... Read more

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    The Role of Excitotoxic Programmed Cell Death Mechanisms

    Edited by Denson G. Fujikawa ...
    Series series Biomedical and Life Sciences (R0)
    Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from ... Read more

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  • Cellular and Molecular Control of Neuronal Migration

    Series series Biomedical and Life Sciences (R0)
    Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of ... Read more

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